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He was laid to rest in his iconic blue denim, a Bible resting in one hand and a guitar in the other

It also appeared that tobacco use affects the quantitative mRNA expression of CYP1B1, the induction of which may be influenced by genetic polymorphisms (Helmig et al., 2010)

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Cigarette Stains on Enamel: The Combined Effect The combined effect of nicotine and tar on tooth enamel is what creates the characteristic appearance of cigarette stains on enamel , a layered discoloration that includes both surface tar deposits and deeply embedded nicotine pigmentation