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Advanced gum disease damages the bone that supports teeth and is one of the leading causes of tooth loss in adults

Early intervention services is a school-based sanctioned service to children who are, or who have been, using or abusing substances, and/or those at risk such as children impacted by a family of addiction and/or have one or more of the following: early sex, chemical/substance use, drop in grades, change in friends, change in appearance (clothes, hygiene, etc.), sudden mood changes, discipline problems, problems with the law, family argument or withdrawing from family, absences, truancy, and increased tardiness

Authors contributions YYY designed the experiment, constructed the plasmids, collected data and interpreted the research results