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IL-8 plays a crucial role in the pathogenesis of chronic inflammation and cancer (Mukaida, Streptococcus pneumonia, Staphylococcus aureus , and viruses, such as influenza A in mice (Sussan et al., Our data suggest that the presence of ROS in flavored e-liquids could play an essential role in the oxidative stress-mediated inflammatory response

Louis Beacon, April 16, 2008: 50 million Americans smoke cigarettes

These results are consistent with other studies that were recently published showing significant cytotoxicity of flavors such as Cinnamon Ceylon on various other cell lines such as epithelial cells and fibroblasts (Bahl et al., in vitro studies in which other investigators have found significant cytotoxicity with menthol flavoring aerosol exposures on epithelial cell lines (Leigh et al., The OX/ROS analysis revealed that all the flavoring chemicals of interest produced significant levels of H 2 O 2 equivalents