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Adaptive trials can make the most efficient use of resources [18] by potentially allowing conclusions to be reached more quickly, and requiring smaller sample sizes on average than traditional trial designs, or avoiding unnecessary use of resources conducting underpowered trials

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These bans risk further escalating tax avoidance, tax evasion, and illicit sales in the U.S.[21] There are already reports of nicotine-containing liquid coming into the U.S

However, the opposite is actually true