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Cardiovascular Effects Acute blood pressure spikes with each pouch, multiple times daily Elevated heart rate with each use Chronic vascular effects nicotine contributes to arterial stiffness over time A 2025 study found regular pouch users showed cardiovascular risk markers that didn't immediately improve even after 12 weeks of quitting Addiction and Dependency Average user: 812 pouches/day Heavy users (men 2534): 14 pouches/day ZYN 6mg = nicotine equivalent of 12 cigarettes At 10 pouches/day at 6mg = 60mg nicotine daily (equivalent to 1020 cigarettes) Withdrawal symptoms include intense cravings, irritability, anxiety, insomnia, difficulty concentrating, increased appetite, and headaches

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After surgery, this irritation can cause: Dryness or inflammation inside the nose Delayed healing of delicate internal tissues Increased mucus production or congestion Potential infection if the surgical site is exposed to contaminants in the vapour When to Stop Ideally, patients should stop all forms of nicotine at least 4 weeks before rhinoplasty and avoid restarting for at least 46 weeks after