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This problem is especially greater in filter recycling methods because the pollutant removal processes from smoked filters by washing will lead to the production of strong leachate 23,24

Therefore, it is most likely that the effects of nortriptyline are mediated by its actions on the norepinephrine transporter

thus, smoking topography (i.e., total puff volume, puff count, puff velocity, duration of puff and puff interval) would be a more appropriate method to estimate any possible change in smoking behaviour (Pauly et al