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Effects such as dizziness, nausea, or headaches can occur if nicotine tolerance is not sufficient

In light of this, the riskbenefit assessment in smokers suggests the use of a lower starting dose than in non-smokers (25 mg instead of 50 mg), with a further dose increase if clinical efficacy is not achieved [66]

In 2023, kretek accounted for over 85% of total cigarette sales in Indonesia, with domestic consumption exceeding 160 billion sticks annually, as reported by the Indonesian Association of Cigarette and Tobacco Producers (GAPCI)

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