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The decline is likely due to several factors, says the report, including local and state restrictions on flavored tobacco product sales, FDA regulatory actions, potential COVID-19associated supply chain disruptions, inflation, and a recent proliferation of large format disposable e-cigarettes capable of delivering thousands of puffs that might permit higher nicotine consumption per unit. As of Dec
4 Unique vulnerabilities of teens and young adults 4.1 The developing adolescent brain and cardiovascular system Adolescence is a critical neurodevelopmental period characterized by significant remodeling of brain circuits, particularly those involving the prefrontal cortex and limbic system, which govern executive function, reward processing, and emotional regulation