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One thing of note here is that NeuroAIDS is not caused by the infection of the virus in the neurons, it is the neurotoxic nature of the virus: such as viral proteins gp120, and oxidative stress exerted by the cytokine dysregulation causing the breakdown of the BBB, leading to neurocognitive dysfunction ( When comparing HIV-1 positive smokers to healthy individuals who smoke, another study found that through the induction of cytochrome P450 enzymes, the metabolism of nicotine is enhanced in patients with HIV-1 (Owe-Larsson et al., 2009)