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without being able to make any claims in regard to its relative risk versus cigarettes, PMI simultaneously applied to the FDA to market IQOS as a modified-risk tobacco product (MRTP)

1998 The Tobacco Master Settlement Agreement (MSA) was entered on November 23, 1998, between the four largest United States tobacco companies and 52 state and territory attorneys generals

The nicotine content in cigarettes varies significantly from brand to brand, but on average, a person absorbs 11.5 milligrams (mg) of nicotine from a cigarette stick