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It's shocking to think it, but randomized controlled clinical trials, the gold standard for medical research in which patients are assigned at random to achieve one of two treatments, were still brand new

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L-OPA1 has been demonstrated to promote mitochondrial fusion, and under conditions of mitochondrial stress, it undergoes proteolytic cleavage to form short OPA1 (S-OPA1) (Lin J

At high levels of consumption, caffeine can cause side effects that range from relatively benign (anxiety, jitters, GI distress, difficulty sleeping) to more worrisome (heart palpitations, high blood pressure, increased heart rate)