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II existe donc un rel besoin de disposer de composs amliors capables d'chapper au systme immunitaire et/ou leur capture par certains organes, par exemple le foie, vitant ainsi leur accumulation dans ces organes.More recently, the use of biodegradable polymer nanoparticles based on poly (alkylcyanoacrylate) has made it possible to improve the degree of encapsulation of Busulfan up to about 5% by weight, as described in J