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Cigarette smoke impairs endothelial function due to vagal input from the airway rather than a specific smoke constituent The ability of blood vessels to widen was examined in the rat study before and after exposure to smoke from four types of classic combustible cigarettes: conventional nicotine, reduced nicotine, conventional nicotine with added menthol, and reduced nicotine with added menthol

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As a hunger suppressant, nicotine seems to follow up on a piece of the cerebrum called the nerve center, at any rate in mice, as uncovered in an investigation by Yale specialists distributed in the June 10, 2011, issue of the diary Science