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After the initial diet-induced weight loss, participants were randomized (1:1:1:1) to one of four treatment arms: placebo + usual physical activity (placebo), placebo + exercise (exercise alone), liraglutide + usual physical activity (liraglutide alone), or liraglutide + exercise (combined treatment)

Propranolol and low-dose isoproterenol ameliorate insulin resistance, enhance beta-arrestin2 signaling, and reduce cardiac remodeling in high-fructose, high-fat diet-fed mice: Comparative study with metformin