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Reconstitute with sterile bacteriostatic water

Preliminary preclinical findings suggest that the stimulation of the PD-1/PD-L1 signaling pathway serves as a mechanism for tumors to provoke T-cell immune reactions specific to antigens [107, 108]

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However, multiple challenges remain: systematically understanding the network interactions among multiple nitrogen metabolism pathways, ensuring interventions act with absolute precision on tumor cells, and addressing the highly heterogeneous and plastic metabolic and epigenetic states within the tumor microenvironment that may lead to treatment resistance