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References 1 AhmedT.GilaniA

Following dosage recommendations did not show serious adverse side effects when taken for less than 12 months, but included stomach upset, breath and urine odor, and seizures in some cases

The mechanism seems to be independent of the catalytic activity, since these effects were not mimicked by systemic DPP-4 inhibition (73, 82), and it was suggested that soluble DPP-4 interacted with caveolin-1 on adipose tissue macrophages, the down-stream effects of which combined with actions of other pro-inflammatory molecules such as factor Xa, to lead to activation of the inflammatory signaling pathway (83) (Figure 3)