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Since there are obvious differences between rodent and human physiology, it cannot be ignored that this may have a significant impact on the efficacy and safety of (any) novel agents

Studies in mice lacking endothelial P-selectin glycoprotein ligand-1 (PSGL-1) and ICAM-1 demonstrate a reduction in activated microglia in the brain parenchyma, indicating a bidirectional communication of inflammation activation stemming from the endothelium (Atangana et al., 2017)

Parental age and risk of childhood cancers: a population-based cohort study from Sweden

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