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When cocultured with PB mononuclear cells, these MenSCs presented increased expression of indoleamine 2,3-dioxygenase-1 and COX-2, as well as elevated secretion of proinflammatory cytokines such as IFN-, IL-10, and monocyte chemoattractant protein-1, suggesting that MenSCs may contribute to disease progression through immunomodulation and altered cellular behavior (Nikoo et al., 2014)

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What is the primary advantage of IGF-1 LR3s hyperplasia effect