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and acts via glutathione (GSH)-dependent mechanisms, with synergistic effects alongside reactive oxygen species (ROS) to exacerbate erythrocyte death Mechanistically, IS induces eryptosis through multiple interconnected pathways: it elevates intracellular Ca 2+ concentrations, triggering membrane phospholipid scrambling and subsequent phosphatidylserine (PS) externalization

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Gradual dose titration significantly reduces the incidence and severity of gastrointestinal symptoms

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