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Further study on the brain injury model of mice induced by Cadmium (Cd) showed that L-theanine could protect mice from Cd-induced neurotoxicity, which was achieved by reducing the level of Cd in the brain and plasma, inhibiting the death of neurons in the cortex and hippocampus, improving the activities of SOD, GSH, and CAT in the brain, and most importantly, significantly alleviating the hyperphosphorylation of tau protein Ser199, Ser202, and Ser396 (26)

In receptor-binding and cellular-signaling research, MT-2 acts as a non-selective agonist across the melanocortin receptors: MC1R (associated with melanocyte pigmentation), MC3R and MC4R (central receptors implicated in energy-homeostasis and appetite research), and MC5R

Buenrostro JD, Giresi PG, Zaba LC, Chang HY, Greenleaf WJ