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As a potential target for treatment development, MOTS-c is expected to be used in the treatment development of a variety of diseases

Finally, beyond their role in controlling metabolic processes, GLP-1 receptor agonists also show promising potential benefits in treating cardiovascular and neurodegenerative diseases

Diabetes Atlas 10th edn (International Diabetes Federation, 2021)

A 2021 clinical trial published in The New England Journal of Medicine the STEP 1 trial showed that participants on semaglutide lost an average of 14.9% of body weight, but research on the body composition breakdown of that loss suggests a meaningful proportion can come from lean mass rather than fat, particularly when protein intake is inadequate