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According to the letter, the effects have so far been insufficiently studied in clinical settings because the trials do not last long enough

A recent report from the Institute for Clinical and Economic Review , an independent nonprofit that evaluates the value of medical treatments, found that GLP-1s such as Ozempic , Wegovy and Zepbound are cost-effective, meaning the medications health benefits justify their price

Importantly, large-scale randomized trials, meta-analyses, and observational studies suggest that GLP-1RAs do not significantly increase AKI risk and may even confer renal benefits in high-risk populations