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5.4 Experimental validation of epigenetic mechanisms Recent technological advances in genome editing and single-cell analysis have provided powerful tools to validate EED-induced epigenetic modifications as causal mechanisms underlying transgenerational reproductive toxicity

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What they found: Cagrilintide 4.5 mg: 10.8 % weight reduction vs 3.0 % placebo (p 40 % of patients achieved 25 % weight reduction , historically unprecedented Safety profile in line with Phase 2 data Why it matters: REDEFINE 1 confirmed CagriSema as the largest body-weight signal reported in the published incretin literature to date