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These directly deplete GSH, causing disruption of mitochondrial Ca 2 homeostasis and inhibition of electron transport chain complexes

Concurrently, its activation of the RhoA/ROCK signaling pathway induces robust contraction of the endothelial actin-myosin cytoskeleton, resulting in enlarged intercellular gaps and thereby collectively exacerbating vascular hyperpermeability, ultimately leading to severe vascular leakage and cerebral edema (107)

doi: 10.1289/EHP6785 19

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