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Pontarollos team (102) has revealed a novel mechanism by which gut microbiota modulate intestinal barrier function: symbiotic bacteria activate TLR-2 signaling in the innate immune receptors of intestinal epithelium, thereby downregulating neuropilin-1 (NRP1) and the Hedgehog signaling pathway it regulates, thus impairing intestinal barrier function

Under normal circumstances, fatty foods trigger the release of cholecystokinin (CCK) and other hormones that slow gastric emptying to allow adequate time for fat digestion and absorption in the small intestine

Duration of effect : Dementia develops over many years (often decades)

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