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- Not for patients with multiple endocrine neoplasia syndrome type 2

Current evidence, including magnetic resonance imaging studies, suggests that skeletal muscle alterations resulting from GLP-1 RA-induced weight loss, such as enhanced insulin sensitivity and reduced muscle fat infiltration, are adaptive, thereby improving muscle quality despite concurrent reductions in lean mass [112]

Your insurer reviews whether you meet their medical necessity criteria (their standards for deciding if a treatment is medically needed for you)things like BMI (body mass index), comorbidities (other health conditions like diabetes or high blood pressure), and sometimes prior medication trials