However, the finding that pretreatment of HL-60 human myeloid leukemia cells with buthionine sulfoxide, an inhibitor of glutathione biosynthesis, did not suppress the antineoplastic effect of JS-K suggests that mechanisms other than the glutathione-activated NO discharge contribute 8
The human PK data gap As of 2026, no completed Phase 1 pharmacokinetic, Phase 2 efficacy, or Phase 3 confirmation trials of BPC-157 have been published in the peer-reviewed clinical trial literature
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Insulin resistance increases aromatase activity