The usage of GLP-1 drugs like Ozempic and Wegovy doubled between 2024 and 2025, according to one Gallup study
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Key monitoring parameters include: Bowel habit changes : Frequency, consistency, and any episodes of diarrhoea or faecal urgency Hydration status : Adequate fluid intake, signs of dehydration, urine output Gastrointestinal symptoms : Severity of nausea, abdominal pain, bloating, or vomiting Weight changes : Monitoring weight loss progress with Wegovy IBS symptom control : Assessment of abdominal pain and bowel satisfaction with linaclotide Nutritional status : Ensuring adequate nutrition despite potential appetite suppression and gastrointestinal symptoms Practical precautions patients should follow include: Taking linaclotide at least 30 minutes before the first meal of the day on an empty stomach, as food reduces its efficacy Administering Wegovy subcutaneously once weekly, on the same day each week, at any time regardless of meals Maintaining adequate hydration, aiming for at least 2 litres of fluid daily (unless fluid restriction is advised due to heart failure, renal disease or other medical conditions) Keeping a symptom diary to track bowel patterns, side effects, and symptom severity Avoiding other medications that may exacerbate diarrhoea without medical advice For patients with type 2 diabetes taking Wegovy, there may be a need to adjust doses of insulin or sulfonylureas to reduce the risk of hypoglycaemia, in line with NICE guideline NG28 recommendations
This matters because glutathione depletion is a common finding in liver disease of various etiologies
