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Pathways such as the Wnt/-catenin, Hippo/YAP, Notch, Hedgehog, TGF-, PI3K-AKT, TNF-, and IL-6 signaling pathways involve complicated systems of receptors, signaling molecules, secondary messengers, transcription factors, and effectors that are crucial for normal liver repair and regeneration
This activation, in turn, drives glycolysis, exacerbating inflammation and promoting a vicious cycle that favors tumorigenesis [53]
No adverse reactions were found in any of the treatments carried, highlighting a good overall tolerability and absence of local effects like seborrhea, itching or dandruff onset