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[3] [4] These medications work through multiple mechanisms: they enhance glucose-dependent insulin secretion, suppress inappropriate glucagon release, and reduce appetite through central nervous system pathways

The potential versatility of incretin mimetics will be tested in coming years, with a long list of additional diseases being studied including short bowel syndrome, including Alzheimers disease, Parkinsons disease, and diabetic eye disease, just to name a few

Metformin absorption can also be affected by delayed gastric emptying, though the clinical significance appears to be less dramatic than with levothyroxine