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A multicenter, randomized, double blind, placebo-controlled phase II study of PL 14736 enema in the treatment of mild-to-moderate ulcerative colitis

The second reason may be a combination of the technical difficulties associated with studying ischemia in neonatal rodents, the overall lower level of interest in development, and the widespread but false perception that mechanisms established in the adult generalize to the neonate only on a smaller scale

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While there is cogent evidence that SE supplementation may reduce occurrence of these adverse events as well as decrease the risk of AIT complications and prevent PP hypothyroidism, the current lack of clear cut-off levels for Se administration, which implicates the risk of overdose, at present tends to militate against Se supplementation in this setting [68]