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Data were obtained from trials with subcutaneous and intravenous administration of semaglutide

At 52 weeks, Tirzepatide led to a resolution of MASH without any worsening of fibrosis in a dose-dependent manner: 44% of patients in the 5 mg group, 56% in the 10 mg group, and 62% in the 15 mg group achieved this endpoint

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Furthermore, GLP-1 analogs may restore insulin secretion by activating the GLP-1 receptor (GLP-1R)-Gs signals because GLP-1 analogs overcome SSTR5-Gi signals in pancreatic -cells under the condition of suppressed insulin production and spare suppressed incretin secretion from intestinal L-cells 27