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Some stated CMS lacks legal authority, as skin substitutes do not meet the statutory definition of an incident-to supply. They stated the reclassification is legally, clinically, and definitionally incorrect, as these products are the primary intervention, not an incidental part of a service, and interact directly with body tissues

Immunopeptides, such as LL-37, regulate innate immunity and provide antibacterial properties, helping to protect the body from illnesses

Hollow microneedles deliver serum through the channel during the act of channel creation itself , which is the only point at which the dermal layer is actually accessible to a topical molecule the size of a peptide

Cell and tissue research , 377 (2), 153159