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They tracked body mass index (BMI) changes during the first year after treatment began and compared them with later health outcomes through June 2025

Heine RJ, Van Gaal LF, Johns D, Mihm MJ, Widel MH, Brodows RG, et al

In microglia, HIV-1 Tat upregulates PTEN-induced kinase 1 (PINK1), Parkin RBR E3 ubiquitin protein ligase (PRKN), and dynamin-1-like protein (DNM1L), marking damaged mitochondria for turnover and promoting fission, yet sequestosome 1 (SQSTM1)-dependent flux is blocked, lowering the mitochondrial membrane potential and fostering microglial activation and neuroinflammation (Fig

Two possible explanations were proposed