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In neovascular AMD, RPE cells generate vascular endothelial growth factor (VEGF) when they are under hypoxia or oxidative stress (4850)

Possible (usually mild) side effects may include: Temporary discomfort or bruising at the injection site Mild headache or nausea in some individuals Rare irritation of the vein (phlebitis) Very rare allergic reactions (screened during pre-treatment assessment) Guided by international clinical standards (Cleveland Clinic, NHS protocols) Serious complications are uncommon when IV infusion therapy is delivered in a controlled clinical setting with appropriate patient selection and monitoring

[10] Non-oral options to consider: Levonorgestrel IUD (Mirena, Liletta): absorption is local and entirely unaffected by GI transit

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