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Activation of the NLRP3 inflammasome is often triggered by environmental allergens, leading to the cleavage of pro-IL1 into its active form via caspase-1, which subsequently promotes a pro-inflammatory milieu conducive to Th17 cell differentiation and neutrophil recruitment [150, 151]

This is largely due to the fact that, while statutory planning within a traditional state framework rooted in nested territorial administrative units and formal tiers of government, regionalization has neither been pursued nor has a regional level of government been established

The study of GPX4-independent ferroptosis pathways can better target ferroptosis to prevent and treat various diseases

doi: 10.1007/s10571-022-01218-3 124