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This review was supported by grants from the Wu Jieping Medical Foundation Research Special Project (no

HIF-1 forms a heterodimer with HIF-1 in the cytoplasm, translocates into the nucleus, and binds specific HREs on DNA, where it acts as a transcription factor for the downstream target gene VEGF ( Figure 3E )

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It is an enzyme that plays a key role in the modulation of catecholdependent functions such as cognition, cardiovascular function, and pain processing