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Potential indirect mechanisms that might theoretically contribute to sensory symptoms include: Rapid weight loss significant caloric restriction can occasionally affect nerve function Nutritional deficiencies reduced food intake may lead to vitamin deficiencies Dehydration gastrointestinal side effects causing fluid loss Electrolyte imbalances particularly with persistent vomiting or diarrhoea It is crucial to emphasise that if numbness or tingling develops during Mounjaro treatment, this warrants proper medical evaluation rather than automatic attribution to the medication

Here we explore why semaglutide causes constipation and what to do about it, with insights from experienced Registered Dietitian, Sarah Nash, RD , and physician, Gia Eapen, MD

Nature Communications (2016) 11