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Given that infusions of GLP-1(2836) and GLP-1 have been shown to influence body weight and blood glucose levels in high-fat dietfed mice (24) and that we ourselves have documented an effect of calorie restriction and weight loss on cardioprotection (25), we examined the consequence of our 14-day infusions on these parameters

The GLP-1 Legacy was written for this second phase

These include: Nausea (very common), typically most pronounced in the first few weeks Vomiting and diarrhoea (common), which can contribute to dehydration Constipation (common), which may require dietary adjustments Abdominal pain and bloating (common), related to delayed gastric emptying Reduced appetite (very common), which whilst therapeutically beneficial for weight loss, may lead to inadequate nutrition if extreme These effects usually diminish over time as tolerance develops

They have widespread in natural products of higher plants, animals, microorganisms and algae