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A proof-of-concept study in 51 patients with chronic neuropathic pain, including 35 with CIPN, demonstrated that 82% had improvement in patient-reported measures of pain, mood, and activity levels (Fallon 2015)

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BPC-157s effects on multiple neurotransmitter systems create theoretical interaction points with psychiatric medications, yet interactions are not well studied. Particular concerns include serotonin syndrome risk when combined with SSRIs (since BPC-157 modulates serotonin in complex regional patterns), unpredictable effects on dopaminergic medications (antipsychotics, ADHD treatments, Parkinsons medications), and unknown interactions with benzodiazepines despite the animal studies showing tolerance prevention