The following Inclusion criteria were applied: 1) only secondary carnitine deficient patients, 2) vivo clinical trials- a) animals, fed on high fat diet, b) human subjects, Obese with or without NAFLD, Type-2 Diabetes, CKD, CVD, fertility issues, 3) intervention-patients received carnitine drug or lysine drug or carnitine/lysine and methionine rich food items in the recommended doses, while the control group received placebo, 4) results- minimum two test results out of many (e.g
Senolytic Peptide FOXO4-DRI Selectively Removes Senescent Cells From in vitro Expanded Human Chondrocytes Huang Y, He Y, Makarcyzk MJ, Lin H Frontiers in Bioengineering and Biotechnology (2021) This study demonstrated that FOXO4-DRI selectively removes senescent cells from human chondrocyte cultures expanded in vitro, providing direct evidence of the peptide's senolytic activity in human cells relevant to joint and cartilage aging
Or it could be caused by changes in the microbiome or by nutritional deficiencies
Anti-glycation action: When carbohydrates attach to proteins, they generate Advanced Glycation End Products (AGEs), which damage collagen and elastin, resulting in wrinkles, sagging, and dull skin
