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103 Care for people with Down syndrome and dementia is especially challenging due to the intellectual, cognitive and communication impairments associated with Down syndrome that are present in addition to the cognitive impairments due to dementia

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Biomarker Effects Were Present Despite clinical failure, semaglutide showed biological activity: CSF biomarkers including pTau181, pTau217, and others demonstrated nominally significant reductions of approximately 10% in treated patients