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The actual impact from commercial spillover is also difficult to estimate as they depend heavily on the specifics of PBM negotiations, but we could expect that the commercial impact would phase in gradually over two to four years following the Medicare pricing shift in 2027

Oral GLP-1 medications may be a reasonable option for: Patients early in their weight loss journey Patients with mild to moderate weight loss goals Patients who strongly prefer to avoid injections They may be less ideal for: Patients who have had bariatric surgery Patients needing significant weight loss Patients who have not responded to oral medications in the past The decision is not just about preference