In turn, these proliferating synovial cells release pro-inflammatory mediators that stimulate the expression of matrix-degrading enzymes and other catabolic factors (Hunter and Bierma-Zeinstra, 2019
Four groups of 20 participants each were formed: the first group received an oral L-carnitine supplement, the second applied a topical lotion containing L-carnitine, the third combined both the supplement and the lotion, and the fourth served as the untreated control group
The intervention group consisted of patients who were prescribed GLP-1 RA medications, including Victoza (Liraglutide 1.8 mg), Saxenda (Liraglutide 3 mg), Ozempic (Semaglutide 1 mg), and Wegovy (Semaglutide 2.4 mg)
Ori, C., Freo, U., Pizzolato, G., & Dam, M