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Bei einer bekannten, vorbestehenden CED sollte eine Behandlung mit einem Anti-IL-17A-Antikrper nur nach sorgfltiger Nutzen-Risiko-Abwgung im Einzelfall erfolgen und dann engmaschig berwacht werden

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3) ( with disulfides is relatively slow in solution, the protein environment and the presence of a better leaving group in trisulfides (a second persulfide, Eq