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Given (i) that during fetal and early postnatal life, the brain is a fast growing organ, thus very high in energy and nutrient demand [10,11,12,13]
Unlike sulfonylureas, they do not cause hypoglycemia, making them the preferred option for many patients [33]
Life Sci 241:117051 Kremer J, Petrillo G, Hamilton R (1995) Pharmacokinetics and renal function in patients with rheumatoid arthritis receiving a standard dose of oral weekly methotrexate: association with significant decreases in creatinine clearance and renal clearance of the drug after 6 months of therapy
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