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Elachouri, G

Family history/genetic predisposition Exposure to pesticides or other toxins like carbon monoxide Brain tumor Viral encephalitis AIDS Chronic constipation Repeated blows to the head (eg, professional fighters or football players) Certain medications Stroke What are the Signs and Symptoms of Parkinsons Disease

doi:10.1016/B978-044452763-9/50052-4

Key areas of investigation include: Gastrointestinal : Demonstrated protection against NSAID-induced ulcers, inflammatory bowel disease models, and esophageal damage in multiple animal studies Musculoskeletal : Accelerated healing of transected Achilles tendons, quadriceps muscles, and medial collateral ligaments in rat models Neurological : Neuroprotective effects in models of traumatic brain injury, nerve crush injury, and dopaminergic system damage Organ protection : Hepatoprotective, cardioprotective, and nephroprotective effects demonstrated in various toxicity models The primary limitation is that all evidence comes from animal models