careful riskbenefit assessment is warranted Those with pre-existing gallbladder disease : Rapid weight loss can precipitate gallstone formation or worsen existing biliary conditions People with severe gastrointestinal disease, including gastroparesis : GLP-1 receptor agonists slow gastric emptying, which may worsen symptoms in those with pre-existing gastric motility disorders Older adults : Age-related changes in renal and hepatic function may affect drug metabolism and increase sensitivity to side effects
You might have heard them being referred to as GLP-1 receptor agonists or peptide weight loss drugs, because of how they work (and not to be sticklers, but technically, Mounjaro is a GLP-1/GIP receptor agonist)
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Fixed-ratio combination products containing both insulin and a GLP-1 receptor agonist are also available, including insulin glargine/lixisenatide (Soliqua) and insulin degludec/liraglutide (Xultophy)
