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Glutathione depletion, pentose phosphate pathway activation, and hemolysis in erythrocytes protecting cancer cells from vitamin C-induced oxidative stress

In contrast, the gdh3 / gdh3 mutant showed overall higher concentrations of intracellular metabolites than the wild-type strain when grown in MM medium, except for 2-aminobutyrate and norvaline.When grown in a proline medium, the gdh3 / gdh3 mutant revealed a significantly higher concentration of glutamate family metabolites (e.g., glutamate, glutamine, and proline) than the wild-type, whilst asparagine, histidine, phenylalanine, valine, leucine, tyrosine, and aspartate family metabolites (e.g., aspartate, isoleucine, and threonine), as well as all saturated fatty acids detected, were at lower concentrations in the gdh3 / gdh3 mutant

In PCa, the enlarged prostate obstructs the urethra, leading to difficulties in urination

Increased arterial stiffness in female-to-male transsexuals treated with androgen