Clinicians should evaluate individual risk factors, comorbidities, and contraindications when choosing patients for treatment, balancing possible benefits with associated dangers
Fortunately, a meta-analysis of SGLT2i CVOTs found that diabetic ketoacidosis was rare, occurring in 0.1 to 2.2 per 1,000 person-years in those treated with a SGLT2i, albeit with a significantly greater risk compared to placebo (HR, 2.46
Generally, low cardiovascular risk is typically defined as the absence of cardiovascular disease and a Flemingham 10-year risk of cardiovascular events less than 20% ( Conclusion In conclusion, our meta-analysis showed that first-line use of SGLT2i and GLP-1RAs in T2DM patients at low cardiovascular disease risk significantly reduced HbA1c, body weight, and FPG levels in T2DM patients compared with placebo
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